Assessment of optic disk by disk damage likelihood scale staging using slit-lamp biomicroscopy and optical coherence tomography in diagnosing primary open-angle glaucoma

Purpose: The current study was aimed at assessment of optic disk by disk damage likelihood scale (DDLS) staging using slit?lamp biomicroscopy and optical coherence tomography (OCT) in diagnosing primary open?angle glaucoma (POAG) patients. Methods: This was a cross?sectional observational study of 106 POAG patients, which was conducted from April 2017 to April 2018. All patients underwent slit?lamp fundoscopy with a +78 D lens and high?definition (HD)?OCT, and the vertical cup disk ratios (VCDRs) were recorded. Disk size and neuroretinal rim assessment were done, and the disk was then staged using the recent version, which stages the optic nerve head (ONH) from 1 to 10 as read from the DDLS nomogram table. DDLS scores >5 indicate glaucomatous damage. Pearson coefficient was used to correlate the DDLS staging by slit?lamp biomicroscopy with best?corrected visual acuity (BCVA), intraocular pressure (IOP), disk size, and VCDR and VCDR, mean deviation, and DDLS staging by HD?OCT. Results: The mean age of the patients was 59.54 ± 6.61 years. The male: female ratio was 2:1. The mean IOP was 16.04 ± 1.97 mmHg, and BCVA was 0.72 ± 0.13 LogMAR units. The mean VCDR on 78 D slit?lamp biomicroscopy was 0.76 ± 0.09 (standard deviation [SD]) (range 0.1–0.77), whereas on HD?OCT, the mean VCDR was 0.81 ± 0.09 (SD) (range 0.07–0.81). The mean deviation on visual field testing in decibels was ?14.43 ± 3.31 (SD). The correlation coefficient between DDLS staging by slit?lamp biomicroscopy and DDLS staging by HD?OCT parameters was r = 0.96. Conclusion: There is a positive correlation between the DDLS system of optic disk evaluation on slit?lamp biomicroscopy and most of the HD?OCT evaluation parameters

Incidence of Pterygium in Teenagers -A Clinical Study

Aim: The aim of our study was to evaluate increasing occurrence of pterygium in young individuals and to suggest methods for its prevention. Methods: This was a hospital based prospective observational study carried out for a period of one year. A total of 30 eyes of 25 patients were taken who were diagnosed to have pterygium on slit lamp examination. All patients were less than 20 years of age. Patients who presented with complaints of irritation, redness and mass in the eyes were included in our study. Patients with history of trauma and chemical injuries were excluded in this study. All selected patients underwent detailed ophthalmic examination including visual acuity, refraction, slit lamp examination and fundus evaluation. The side, progression, position, autorefractometry and keratometry were noted in each and every patient. Results: A total of 30 eyes of 25 patients were included in our study among which 21 (84.0%) were males and rest 4 (16.0%) females. All of our patients belonged to age group 11-20 yrs. The complaint of pterygium was found more in patients who belonged to rural background (18, 72.0%). 5 (20.0%) patients had bilateral pterygium and rest 20 (80.0%) had complaint in only one eye. Majority of our patients had pterygium on nasal side (21, 84.0%), 3 of them on temporal side (12.0%) and one on both sides (4.0%). Majority of them had concern with cosmesis followed by diminution in vision and irritation in the eyes. Almost all of them (24, 96.0%) spent their time outdoors while work and play. Pterygium was graded as grade 1 when it just touched the limbus, grade 2 when pterygium was at half the distance between the limbus and pupillary margin, grade 3 when pterygium reached the pupillary margin and grade 4 when it crossed the visual axis to the other side. All of our patients had grade 1 and 2 pterygium. Conclusion: The prevalence of pterygium has been on a rise in these recent years in young individuals. Hence, adequate precautions like wearing protective glasses, hooded caps, brimmed hats etc. should be advised to young individuals in order to prevent them from pterygium. All of them should be educated for safety measures in order to prevent pterygium and hence to lead a good quality of life.

Study Of Prevalence Of Hypothyroidism In Type 2 Diabetes Mellitus Patients Of Lucknow And Surrounding Areas

Diabetes mellitus and thyroid hormone dysfunction are two common endocrinopathies seen in adult population. Insulin and thyroid hormones are intimately involved in cellular metabolism, so excess or deficit of any of them can derange the function of another. To see the prevalence of hypothyroidism in type 2 Diabetes Mellitus patients. Atotal of 235 patients with diagnosed Type 2 Diabetes Mellitus of either sex, aged >20 years were included in the study. Analysis of serum TSH by ELISAwas done in all patients of the study. Atotal of 235(107 males and 128 females) Type 2 Diabetes Mellitus patients were included in the study. Hypothyroidism was seen in 48(20.4%) patients. Hyperthyroidism was seen in 17(7.2%) patients. Euthyroid patients were 170(72.3%). Out of 128 females 27(11.4%) had hypothyroidism whereas out of 107 males 21(8.9%) had hypothyroidism. We conclude that prevalence of hypothyroidism was 20.4% and seen more in female Type 2 Diabetic patients as compared with male patients

Status Of Tnf-α And Insulin In Obese And Diabetic Obese Subjects Of Western Lucknow

Obesity has become a matter of quality to health care administrators. The busy lifestyle of people made them prefer fast food instead of taking healthy food. But the people are not aware that fast food habit converts to the disease like obesity, type 2 diabetes mellitus (T2DM), dyslipoproteinemia etc. This case control study had been carried out in department of Physiology in collaboration of Department of Biochemistry and Medicine, Era's Lucknow Medical College & Hospital, Lucknow to explore status blood sugar fasting (BSF), tumor necrosis factor-α (TNF- α), Insulin by standard spectrophotopmetric kit methods, blood pressure (BP) as well as anthropometric measurements with the help of suitable instruments and equipments in Control group, Obese group and Obese with type 2 diabetic group. Values of all above parameters were found increased in obese group with respect to control group and values of all these parameters were found increase in obese with type 2 Diabetes mellitus group with respect to obese group. Thus it is clear that obesity is risk factor for T2DM, Dyslipoproteinemia and coronary artery disease (CAD).

Characterization of the molluscicidal activity of Bauhinia variegata and Mimusops elengi plant extracts against the fasciola vector lymnaea acuminata / Caracterização da atividade moluscicida dos extratos das plantas Bauhinia variegata e Mimusops elengi contra o vetor da Fasciola, Lymnaea acuminata

The molluscicidal activity of Bauhinia variegata leaf and Mimusops elengi bark was studied against vector snail Lymnaea acuminata. The toxicity of both plants was time and concentration-dependent. Among organic extracts, ethanol extracts of both plants were more toxic. Toxicity of B. variegata leaf ethanolic extract (96h LC50- 14.4 mg/L) was more pronounced than M. elengi bark ethanolic extract (96h LC50-15.0 mg/L). The 24h LC50 of column purified fraction of B. variegata and M. elengi bark were 20.3 mg/L and 18.3 mg/L, respectively. Saponin and quercetin were characterized and identified as active molluscicidal component. Co-migration of saponin (Rf 0.48) and quercetin (Rf 0.52) with column purified bark of M. elengi and leaf of B. variegata on thin layer chromatography demonstrate same Rf value i.e. 0.48 and 0.52, respectively. The present study clearly indicates the possibility of using M. elengi and/or B. variegata as potent molluscicide.

A atividade moluscicida das folhas da Bauhinia variegata e da casca do Mimusops elengi foi testada contra o vetor caracol, Limnaea acuminata. A toxicidade de ambas as plantas é dependente do tempo e da concentração. Entre os extratos orgânicos, os extratos de etanol de ambas as plantas foi mais tóxico. A toxicidade do extrato etanólico da folha da B. variegata (96 h LC50 - 14,4 mg/L) foi mais pronunciada do que o extrato etanólico da casca do M. elengi (96h - LC50 - 15,0 mg/L). As frações purificadas em coluna durante 24 h LC50 do B. variegata e da casca do M. elengi foram 20,3 mg/L e 18,3 mg/L, respectivamente. A saponina e a quercentina foram caracterizadas e identificadas como os componentes ativos moluscicidas. A co-migração da saponina (Rf 0,48) e da quercentina (Rf 0,52) com a casca purificada por coluna do M. elengi e as folhas da B. variegata na cromatografia demonstraram o mesmo valor Rf isto é, 0,48 e 0,52 respectivamente. O presente estudo indica claramente a possibilidade de usar M. elengi e/ou B. variegata como moluscicidas potentes.

Study of medico-legal case management in tertiary Care Hospital.

Article 21 of the constitution guarantees protection of life and liberty to every citizen as well as non-citizens. Right to health care and medical assistance is integral to the right to life and the state has a constitutional obligation to provide health facilities. Failure of a government and other hospital to provide a patient timely medical treatment results in violation of the patient‘s right to life. The study comprising about medicolegal case (MLC) management, awareness and prevalent practices among the health care professionals especially among those who directly or indirectly involve with treatment of patients. As for awareness is concern regarding especially regarding procedural awareness, the documentation and various other medico-legal issues were studied in detail. Contrary to the popular belief that doctors who deals with the extreme situation of life but suffer some kind of medicolegal phobia in his work except few especially those who are in feeling of government immunity have genuine or in-genuine boldness in dealing with medicolegal cases.

Mycosporine-like amino acids (MAAs): chemical structure, biosynthesis and significance as UV-absorbing/screening compounds.

Continuous depletion of the stratospheric ozone layer has resulted in an increase in ultraviolet-B (UV-B; 280-315 nm) radiation on the earth's surface which inhibits photochemical and photobiological processes. However, certain photosynthetic organisms have evolved mechanisms to counteract the toxicity of ultraviolet or high photosynthetically active radiation by synthesizing the UV-absorbing/screening compounds, such as mycosporine-like amino acids (MAAs) and scytonemin besides the repair of UV-induced damage of DNA and accumulation of carotenoids and detoxifying enzymes or radical quenchers and antioxidants. Chemical structure of various MAAs, their possible biochemical routes of synthesis and role as photoprotective compounds in various organisms are discussed.